منابع مشابه
Masters of Immunology The Colony-Stimulating Factors and Cancer
The colony-stimulating factors (CSF) are the master regulators of granulocyte and macrophage populations. There are four different aspects of the connection between the CSFs and cancer: (i) the CSFs can accelerate the regeneration of protective white cells damaged by chemotherapy; (ii) the CSFs can mobilize stem cells to the peripheral blood in convenient numbers for transplantation; (iii) the ...
متن کاملColony stimulating factors and macrophage heterogeneity
Macrophages or mononuclear phagocytes are heterogeneous populations present throughout the body which can adapt quite dramatically to the surrounding milieu, both in the steady state and during immune/inflammatory responses. To assist in our understanding of this diversity, they have been classified into polarization or “activation” states, termed M1 and M2, respectively. This in vitro classifi...
متن کاملHaemopoietic colony stimulating factors for preterm neonates.
Bacterial and fungal sepsis is a major cause of morbidity and mortality in neonates. Infection rates are high in infants treated in intensive care units, with the highest rates, of around 30%, occurring in extremely immature preterm neonates. A survey of neonatal infection at Yale University, ongoing since 1928, has documented a decline in neonatal septic deaths commensurate with the establishm...
متن کاملColony Stimulating Factors: Regulation of Production
Life span of mature blood cells is ephemeral, reqUIrIng hematopoiesis throughout life. A complex network of hematopoietic progenitor cells and cytokines maintain an enormous daily production of granulocytes, monocytes, erythrocytes, platelets, and lymphocytes. This population of hematopoietic cells must be able to respond rapidly to changing needs such as bleeding, infections, cancer, or exposu...
متن کاملThe nature and action of granulocyte-macrophage colony stimulating factors.
Granulocyte-macrophage colony stimulating factor (GM-CSF) stimulates the in vitro proliferation and differentiation of granulocytic and macrophage cells. This regulator is now known to act at other levels of hemopoietic regulation. The heterogeneity of GM-CSFs is not only related to the tissue of origin and the in vitro production method, but also to functional subclasses of the molecule that h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2010
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc2843